Biosafety guidelines are a set of policies, rules, and procedures necessary to observe by personnel working in various facilities handling microbiological agents such as bacteria, viruses, parasites, fungi, prions, and other related agents and microbiological products. Institutions requiring strict adherence to these biosafety guidelines include clinical and microbiological laboratories, biomedical research facilities, teaching and training laboratories and other healthcare institutions (e.g., clinics, health centers, hospital facilities). These guidelines are intended to provide proper management and regulation of biosafety programs and practices implemented at all levels of the organization. Essential components of the biosafety guidelines contain some or all the following, depending on the facility: microbiological risk assessment and identification; specific biosafety measures, which cover the code of practice, physical plant such as laboratory design and facilities, equipment acquisition and maintenance, medical surveillance, staff training, safe handling of chemicals, with fire, radiation and electricity safety, among others. Additional components may be included such as commissioning and certification guidelines for the facilities. Biosafety guidelines must be made clear, practical and suitable for each facility and must be available for easy reference by all staff, must be reviewed, and updated regularly. While it provides guidance in the application of biosafety practices, this technical guide cannot solely ensure a safe working environment without the commitment of each person to adhere adequately to the biosafety guidelines at all times. Continuous research on biosafety can improve the development of future guidelines[1] REFERENCE:Bayot ML, Limaiem F. Biosafety Guidelines. 2019 Jan 31. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2018 Jan-. PubMed PMID: 30725895. ----------------------------------------------------------- Sigue este Blog en Facebook y Twitter Ayúdanos a traducir las fichas de seguridad de microorganismos. www.seguridadbiologica.blogspot.com ----------------------------------------------------------- […]

Background: The prevalence of disinfectant resistance in Pseudomonas aeruginosa is on the rise. P. aeruginosa is the most common bacteria isolated from cases of microbial keratitis. Many multi-purpose contact lens disinfectant solutions are available to decontaminate contact lenses before use and to help reduce the incidence of infections. However, with increasing disinfectant resistance, the effect of multi-purpose disinfectant solutions may diminish. The goal of this study was to examine genes associated with disinfectant resistance in ocular isolates of P. aeruginosa and understand the strain’s susceptibility to different multipurpose disinfectant solutions. Methods: Seven potential disinfectant resistance genes were used in BLASTn searches against the whole genomes of 13 eye isolates of P. aeruginosa. A microdilution broth method was used to examine susceptibility to four different multipurpose disinfectant solutions. Results: All strains possessed the sugE2, sugE3 and emrE (qacE) genes. The sugE1 and qacEdelta1 genes were present in 6/13 isolates. No strains contained the qacF or qacG genes. All tested disinfectant solutions had the ability to kill all test strains at 100% concentration, with some strains being susceptible at 1:8 dilutions of the disinfecting solutions. However, the presence of disinfectant resistance genes was not associated with susceptibility to multi-purpose disinfectants. Conclusion: All four tested contact lens disinfectant preparations are effective against P. aeruginosa isolates regardless of the presence of disinfectant resistance genes. REFERENCE: Subedi, Dinesh et al. “Study of Disinfectant Resistance Genes in Ocular Isolates of Pseudomonas aeruginosa” Antibiotics (Basel, Switzerland) vol. 7,4 88. 15 Oct. 2018, doi:10.3390/antibiotics7040088 ----------------------------------------------------------- Sigue este Blog en Facebook y Twitter Ayúdanos a traducir las fichas de seguridad de microorganismos. www.seguridadbiologica.blogspot.com ----------------------------------------------------------- […]

Background: Many antineoplastic (chemotherapeutic) drugs are known or probable human carcinogens, and many have been shown to be reproductive toxicants in cancer patients. Evidence from occupational exposure studies suggests that health care workers who have long-term, low-level occupational exposure to antineoplastic drugs have an increased risk of adverse reproductive outcomes. It's recommended that, at minimum, nurses who handle or administer such drugs should wear double gloves and a nonabsorbent gown to protect themselves. But it's unclear to what extent nurses do. Purpose: This study assessed glove and gown use by female pregnant and nonpregnant nurses who administer antineoplastic drugs in the United States and Canada. Methods: We used data collected from more than 40,000 nurses participating in the Nurses’ Health Study 3. The use of gloves and gowns and administration of antineoplastic drugs within the past month (among nonpregnant nurses) or within the first 20 weeks of pregnancy (among pregnant nurses) were self-reported via questionnaire. Results: Administration of antineoplastic drugs at any time during their career was reported by 36% of nonpregnant nurses, including 27% who reported administering these drugs within the past month. Seven percent of pregnant nurses reported administering antineoplastic drugs during the first 20 weeks of pregnancy. Twelve percent of nonpregnant nurses and 9% of pregnant nurses indicated that they never wore gloves when administering antineoplastic drugs, and 42% of nonpregnant nurses and 38% of pregnant nurses reported never using a gown. The percentage of nonpregnant nurses who reported not wearing gloves varied by type of administration: 32% of those who administered antineoplastic drugs only as crushed pills never wore gloves, compared with 5% of those who administered such drugs only via infusion. Conclusion: Despite longstanding recommendations for the safe handling of antineoplastic and other hazardous drugs, many nurses—including those who are pregnant—reported not wearing protective gloves and gowns, which are considered the minimum protective equipment when administering such drugs. These findings underscore the need for further education and training to ensure that both employers and nurses understand the risks involved and know which precautionary measures will minimize such exposures. REFERENCE: Lawson, Christina C., et al. Antineoplastic Drug Administration by Pregnant and Nonpregnant Nurses. An Exploration of the Use of Protective Gloves and Gowns. AJN The American Journal of Nursing: January 2019 - Volume 119 - Issue 1 - p 28–35 ----------------------------------------------------------- Sigue este Blog en Facebook y Twitter Ayúdanos a traducir las fichas de seguridad de microorganismos. www.seguridadbiologica.blogspot.com ----------------------------------------------------------- […]

Environmental contamination plays an important role in the transmission of MRSA, VRE, and C. difficile. Suboptimal compliance with hand hygiene or inappropriate glove use can result in indirect transfer of these pathogens to patients. This study evaluates a novel disinfectant that claims to kill microbes on surfaces for ≥24 hours. REFERENCES: Rutala, William et al. “1727. Sustained Antimicrobial Activity of a Novel Disinfectant Against Healthcare Pathogens” Open Forum Infectious Diseases vol. 5,Suppl 1 S55. 26 Nov. 2018, doi:10.1093/ofid/ofy209.133 ----------------------------------------------------------- Sigue este Blog en Facebook y Twitter Ayúdanos a traducir las fichas de seguridad de microorganismos. www.seguridadbiologica.blogspot.com ----------------------------------------------------------- […]

Las normas consignadas en el Código Sanitario para los Animales Terrestres (Código Terrestre) buscan mejorar la sanidad y el bienestar animal al igual que la salud pública veterinaria en todo el mundo. Con este fin, prevé textos normativos para garantizar el comercio internacional seguro de animales terrestres (mamíferos, reptiles, aves y abejas) y de sus productos derivados. Las autoridades veterinarias de los países importadores y exportadores deberán referirse a las medidas sanitarias que en él figuran durante las actividades de detección temprana, notificación y control de agentes patógenos con el fin de evitar su transmisión a los animales y, en caso de enfermedades zoonóticas, a las personas, así como su diseminación a través de los intercambios internacionales de animales y de productos derivados, impidiendo al mismo tiempo la instauración de barreras sanitarias injustificadas. Las medidas sanitarias del Código Terrestre han sido adoptadas oficialmente por la Asamblea Mundial de Delegados de los Miembros de la OIE. La vigésima séptima edición incorpora las modificaciones del Código Terrestre aprobadas en la 86.ª Sesión general de mayo de 2018.CONSULTA EN LINEA EN ESPAÑOL ----------------------------------------------------------- Sigue este Blog en Facebook y Twitter Ayúdanos a traducir las fichas de seguridad de microorganismos. www.seguridadbiologica.blogspot.com ----------------------------------------------------------- […]